Research

Research

 
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The Armstrong laboratory is focused on defining the genetic and epigenetic mechanisms of cancer development with a focus on pediatric leukemia. By defining the programs that control the extensive self-renewal properties associated with leukemia, we can develop rational approaches for potential new therapies. Experiments incorporate the use of sophisticated mouse models of leukemia and the characterization of human leukemia cells. Current active research areas include:

 

  • Identification of developmental pathways that are responsible for cancer stem cell self-renewal and characterization of their specific roles in this process
  • Characterization of histone methylation in leukemias, and assessment of the role of specific histone methyltransferases as potential therapeutic targets in leukemia
  • Development of mouse models for testing novel therapeutic approaches
  • Detailed genomic and epigenomic characterization of human and mouse leukemias through the use of next-generation sequencing approaches